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ACRP ACRP-CP : ACRP Certified Professional Exam

Exam Code: ACRP-CP

Exam Name: ACRP Certified Professional Exam

Updated: Oct 05, 2026

Q & A: 127 Questions and Answers

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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Data Management and Informatics17%- Data collection
  • 1. Electronic data capture systems
  • 2. Case report form design and completion
- Data quality control
  • 1. Query management and resolution
  • 2. Data validation and cleaning
- Data reporting
  • 1. Data integrity and security
  • 2. Database lock and data transfer
Professionalism and Ethical Practice15%- Professional standards
  • 1. Confidentiality and conflict of interest
  • 2. Role responsibilities and boundaries
- Continuous improvement
  • 1. Quality assurance and process improvement
  • 2. Professional development and education
Study Design and Conduct17%- Study planning
  • 1. Protocol development and amendments
  • 2. Study population and eligibility criteria
  • 3. Sample size and statistical considerations
- Study implementation
  • 1. Study monitoring and oversight
  • 2. Site selection and activation
  • 3. Investigational product management
Clinical Study Operations15%- Project management
  • 1. Timeline and budget management
  • 2. Vendor and stakeholder management
- Site management
  • 1. Site personnel training and delegation
  • 2. Study documentation and record keeping
Regulatory and Compliance Requirements17%- International standards
  • 1. Declaration of Helsinki
- Compliance procedures
  • 1. Audits and inspections
  • 2. Regulatory submissions and approvals
- ICH Guidelines
  • 1. E6(R2)/E6(R3) Good Clinical Practice
  • 2. E2A Expedited Reporting
  • 3. E9 Statistical Principles
  • 4. E8 General Considerations for Clinical Trials
  • 5. E11 Pediatric Trials
Ethical and Participant Safety Considerations19%- Ethical principles
  • 1. Clinical equipoise and therapeutic misconception
  • 2. Human subject protections and privacy
- Safety monitoring and reporting
  • 1. Safety information evaluation and communication
  • 2. Adverse event identification and classification
- Clinical care and management of research participants
  • 1. Standard of care vs protocol requirements
  • 2. Informed consent development and review
  • 3. Continuity of medical care

ACRP Certified Professional Sample Questions:

Question #1

A PI is being considered for an industry-sponsored study. The PI sees approximately 20 patients per month who meet the study criteria. The PI does not have access to a Positron Emission Tomography (PET) scanner, which is required for the protocol. The PI is already taking part in three other studies. Should the Sponsor choose this PI?

  • A. No, the PI is taking part in too many ongoing studies to participate in this study.
  • B. Yes, the PI has a sufficient patient population to take part in this study.
  • C. Yes, the PI can perform other imaging scans instead of the PET scans.
  • D. No, the PI does not have the resources to perform all protocol-required procedures.
Reveal Solution  Discussion  0

Correct Answer: D  🗳️

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Question #2

At a close-out visit, which document should be retained only at the site?

  • A. Subject identification code list
  • B. Final trial close-out monitoring report
  • C. IP accountability
  • D. Treatment allocation
Reveal Solution  Discussion  0

Correct Answer: A  🗳️

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Question #3

Who on the local site research study team is accountable for the unblinding documentation of IP?

  • A. PI
  • B. Regulatory manager
  • C. Pharmacist
  • D. CRC
Reveal Solution  Discussion  0

Correct Answer: A  🗳️

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Question #4

The objective of a randomized clinical trial is to look at whether an IP is effective in preventing recurrence of a disease. What would be a possible primary endpoint of the trial?

  • A. Occurrence of known side effects of the IP
  • B. Use of concomitant medications to treat the symptoms
  • C. Time to occurrence of symptoms of the disease
  • D. Impact of an approved vaccine against the disease
Reveal Solution  Discussion  0

Correct Answer: C  🗳️

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Question #5

A potential subject is interested in a new clinical trial and would like to learn more about the risks and benefits of participation. Where can they find this information?

  • A. Package insert
  • B. IB
  • C. ICF
  • D. Protocol
Reveal Solution  Discussion  0

Correct Answer: C  🗳️

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